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| CHEMICAL
COMPOSITION Leaves contain several O-iso-propylidene derivatives of gymnemagenin, a hexahydro-terpene, crystalline gymnemagenin, gymnestrogenin1,2 and gymnemic acid (the antisweet principle) which was a complex mixture of atleast nine closely related acidic glycosides3. |
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PHARMACOLOGY |
| THERAPEUTIC
USES It is used as an antidiabetic. It stimulates the heart and circulatory system, activates the uterus and increases urine secretion8. Gymnemic acids are useful for prevention of the formation of dental plaque and caries7. |
Leaves
are found to be antidiabetic3, and
insulinotropic5. The active principles
which have been identified as glycosides (several gymnemic acids)
suggest that the topical and selective anaesthetic effect of
the plant might result from the competition of the receptor
sites between glycosides and the sweet substances6.
Gymnemic acids inhibited glucan formation by streptococcus mutans
in vivo and also markedly inhibited the activity of glucosyltransferase
from bacterial coat of S.mutans.|
SPECIFICATIONS: GYMNEMA SYLVESTRE EXTRACT General Information:
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